We developed a novel molecular magnetic resonance (MR) imaging method to monitor accumulation of macrophages at the infection site infection. Positive-contrast molecular MR imaging provides an alternative to negative-contrast molecular MRI imaging, exploiting the chemical shift induced by ultra-small superparamagnetic iron-oxide (USPIO) nanoparticles to nearby water molecules. We introduced a novel combination of off-resonance (ORI) positive-contrast MRI and T2p relaxation in the rotating frame (ORI-T2()) for positive-contrast MR imaging of USPIO. We used this new method for testing a new anti-infective compound M50 following Pseudomonas aeruginosa infection..

Combined off-resonance imaging and relaxation in the rotating frame for positive contrast imaging of infection in a murine burn model testing a novel anti-infective compound.

RIGHI, VALERIA;TUGNOLI, VITALIANO;
2011

Abstract

We developed a novel molecular magnetic resonance (MR) imaging method to monitor accumulation of macrophages at the infection site infection. Positive-contrast molecular MR imaging provides an alternative to negative-contrast molecular MRI imaging, exploiting the chemical shift induced by ultra-small superparamagnetic iron-oxide (USPIO) nanoparticles to nearby water molecules. We introduced a novel combination of off-resonance (ORI) positive-contrast MRI and T2p relaxation in the rotating frame (ORI-T2()) for positive-contrast MR imaging of USPIO. We used this new method for testing a new anti-infective compound M50 following Pseudomonas aeruginosa infection..
2011
19th Annual Proceedings of the International Society of Magnetic Resonance of Medicine Scientific Meering and Exibition
923
923
V. Righi; M. Starkey; J. He; G. Dai; V. Tugnoli; L.G. Rahme; R.G. Tompkins; A.A. Tzika
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/112596
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