The concept of anaplastic large-cell lymphoma (ALCL) has changed over the years because of a stream of new information and novel understanding regarding the cell of origin, biology, genetics, and clinical features of these neoplasms. This new information has led to the current classification proposed by the expert reviewers of the World Health Organization. The objective of this review is to present the most updated information on the cytologic and histologic features of these entities, with a special reference to diagnostic algorithms. A detailed description of the genetic aberrations and the pathogenetic mechanisms leading to transformation is presented. The clinical features of ALCL and novel tailored strategies are briefly illustrated
Anaplastic large cell lymphoma. Sem. Diagn. Pathol / Inghirami G; Pileri S A; European T-Cell Lymphoma Study Group: […; R. Chiarle; G. Cuccuru; B. Martinoglio; E. Medico; E. Pellegrino; R. Piva ML. Ruberto; A. Fornari; D. Novero; M. Chilosi; A. Zamó; F. Facchetti; S. Lonardi; A. De Chiara; F. Fulciniti; C. Doglioni; M. Ponzoni; L. Agnelli; A. Neri; K. Todoerti; C. Agostinelli; PP. Piccaluga; B. Falini; E. Tiacci; P. Van Loo; T. Tousseyn; C. De Wolf-Peeters; E. Geissinger; HK. Muller-Hermelink; A. Rosenwald; MA. Piris MA; ME.Rodriguez; …]. - In: SEMINARS IN DIAGNOSTIC PATHOLOGY. - ISSN 0740-2570. - STAMPA. - 28:(2011), pp. 190-201. [10.1053/j.semdp.2011.03.002]
Anaplastic large cell lymphoma. Sem. Diagn. Pathol
PILERI, STEFANO;AGOSTINELLI, CLAUDIO;PICCALUGA, PIER PAOLO;
2011
Abstract
The concept of anaplastic large-cell lymphoma (ALCL) has changed over the years because of a stream of new information and novel understanding regarding the cell of origin, biology, genetics, and clinical features of these neoplasms. This new information has led to the current classification proposed by the expert reviewers of the World Health Organization. The objective of this review is to present the most updated information on the cytologic and histologic features of these entities, with a special reference to diagnostic algorithms. A detailed description of the genetic aberrations and the pathogenetic mechanisms leading to transformation is presented. The clinical features of ALCL and novel tailored strategies are briefly illustratedI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
