Different calorimetric techniques coupled with chemical analyses and ecotoxicological bioassay led to the proposal of a suitable protocol for the definition of a Key Safety Indicator (KSI) useful to rank the hazard of a compound with respect to the toxicological profile of its thermal decomposition products. The method was applied to Fenitrothion, a phosphorganic pesticide. Similar results were obtained using either adiabatic and isothermal calorimetry, both with respect to the decomposition products identified and to their toxicological profile. This allows to exclude a priori the necessity of carrying out the larger-scale time-consuming adiabatic experiments.

Toxicological Characterization of the Thermal Decomposition Products of Chemicals: a New Approach to an old Problem

COZZANI, VALERIO
2011

Abstract

Different calorimetric techniques coupled with chemical analyses and ecotoxicological bioassay led to the proposal of a suitable protocol for the definition of a Key Safety Indicator (KSI) useful to rank the hazard of a compound with respect to the toxicological profile of its thermal decomposition products. The method was applied to Fenitrothion, a phosphorganic pesticide. Similar results were obtained using either adiabatic and isothermal calorimetry, both with respect to the decomposition products identified and to their toxicological profile. This allows to exclude a priori the necessity of carrying out the larger-scale time-consuming adiabatic experiments.
2011
Proc. 10th International Conference on Chemical and Process Engineering
1123
1128
R. Sanchirico; G. Pinto; A. Pollio; M. Cordella; V. Cozzani
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/107615
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