Folates are water-soluble B-group vitamin that are cofactors in many metabolic pathways such as DNA synthesis and methylation pathways. Humans cannot synthesize folate and its low status has been implicated in a wide variety of disorders. Naturally occurring food folates occur in abundance in leafy green vegetables, yeast extracts, citrus fruit, liver and kidney. Folate could derived, other than from diet, from indigenous bacteria of the microbiota which posses the ability of de novo folate production. Intestinal bacteria such as bifidobacteria can produce this cofactor by themselves from simple precursors; howewer some bifidobacteria are auxotrophic and have a strict growth requirement for folic acid. The study of folate metabolism in bifidobacteria isolated from different animals, such as omnivorous, herbivorous and carnivorous, could advances the knowledge of host-interaction in relation to endogenous folate production for possible microbiota modulation. We aimed to investigate the production of folate by bifidobacteria isolated from animals differing in diet in order to assess the potential indigenous contribute of folate availability provided by the microbiota.We aimed to investigate the production of folate by bifidobacteria isolated from animals differing in diet in order to assess the potential indigenous contribute of folate availability provided by the microbiota.
Folate production in bifidobacteria from omnivores, herbivores and carnivores / D'Aimmo M. R.; Andlid T.; Mattarelli P.; Biavati B.; Modesto M.; Sgorbati B.. - In: GUT. - ISSN 0017-5749. - STAMPA. - 43 (suppl. 1):(2011), pp. A 175-A 175. (Intervento presentato al convegno 19th UEGW Stockolm, 2011 tenutosi a Stoccolma nel 22-26 october 2011).
Folate production in bifidobacteria from omnivores, herbivores and carnivores
MATTARELLI, PAOLA;BIAVATI, BRUNO;MODESTO, MONICA MARIANNA;SGORBATI, BARBARA
2011
Abstract
Folates are water-soluble B-group vitamin that are cofactors in many metabolic pathways such as DNA synthesis and methylation pathways. Humans cannot synthesize folate and its low status has been implicated in a wide variety of disorders. Naturally occurring food folates occur in abundance in leafy green vegetables, yeast extracts, citrus fruit, liver and kidney. Folate could derived, other than from diet, from indigenous bacteria of the microbiota which posses the ability of de novo folate production. Intestinal bacteria such as bifidobacteria can produce this cofactor by themselves from simple precursors; howewer some bifidobacteria are auxotrophic and have a strict growth requirement for folic acid. The study of folate metabolism in bifidobacteria isolated from different animals, such as omnivorous, herbivorous and carnivorous, could advances the knowledge of host-interaction in relation to endogenous folate production for possible microbiota modulation. We aimed to investigate the production of folate by bifidobacteria isolated from animals differing in diet in order to assess the potential indigenous contribute of folate availability provided by the microbiota.We aimed to investigate the production of folate by bifidobacteria isolated from animals differing in diet in order to assess the potential indigenous contribute of folate availability provided by the microbiota.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
