Oxindoles containing a spiro quaternary stereogenic center as part of a pyrrolidinyl or cyclohexyl ring, are a privileged structural core of natural and synthetic alkaloids, which exhibit important biological and medicinal activity.With the aim of expanding our previous studies on the enantioselective synthesis of spiro compounds with an oxindole as a core feature, we decided to investigate the unprecedented enantioselective nitrocyclopropanation of oxindoles
Organocatalytic Michael–Alkylation Cascade: The Enantioselective Nitrocyclopropanation of Oxindoles
PESCIAIOLI, FABIO;RIGHI, PAOLO;MAZZANTI, ANDREA;BARTOLI, GIUSEPPE;BENCIVENNI, GIORGIO
2011
Abstract
Oxindoles containing a spiro quaternary stereogenic center as part of a pyrrolidinyl or cyclohexyl ring, are a privileged structural core of natural and synthetic alkaloids, which exhibit important biological and medicinal activity.With the aim of expanding our previous studies on the enantioselective synthesis of spiro compounds with an oxindole as a core feature, we decided to investigate the unprecedented enantioselective nitrocyclopropanation of oxindolesFile in questo prodotto:
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