Gastrointestinal stromal tumors (GISTs) are rare, but represent the most common mesenchymal neoplasms of the gastrointestinal tract. Tumor resection is the treatment of choice for localized disease. Tyrosine kinase inhibitors (imatinib, sunitinib) are the standard therapy for metastatic or unresectable GISTs. GISTs usually metastasize to the liver and peritoneum. Bone metastases are uncommon. We describe three cases of bone metastases in patients with advanced GISTs: two women (82 and 54 years of age), and one man (62 years of age). Bones metastases involved the spine, pelvis and ribs in one patient, multiple vertebral bodies and pelvis in one, and the spine and iliac wings in the third case. The lesions presented a lytic pattern in all cases. Two patients presented with multiple bone metastases at the time of initial diagnosis and one patient after seven years during the follow-up period. This report describes the diagnosis and treatment of the lesions and may help clinicians to manage bones metastases in GIST patients.

Three cases of bone metastases in patients with gastrointestinal stromal tumors / V. Di Scioscio; L. Greco; M. Pallotti; M. Pantaleo; A. Maleddu; M. Nannini; A. Bazzocchi; M. Di Battista; A. Mandrioli; C. Lolli; M. Saponara; G. Garzillo; G. Biasco; M. Zompatori. - In: RARE TUMORS. - ISSN 2036-3605. - ELETTRONICO. - 3:2(2011), pp. e17.51-e17.53. [10.4081/rt.2011.e17]

Three cases of bone metastases in patients with gastrointestinal stromal tumors

NANNINI, MARGHERITA;SAPONARA, MARISTELLA;GARZILLO, GIORGIO;BIASCO, GUIDO;ZOMPATORI, MAURIZIO
2011

Abstract

Gastrointestinal stromal tumors (GISTs) are rare, but represent the most common mesenchymal neoplasms of the gastrointestinal tract. Tumor resection is the treatment of choice for localized disease. Tyrosine kinase inhibitors (imatinib, sunitinib) are the standard therapy for metastatic or unresectable GISTs. GISTs usually metastasize to the liver and peritoneum. Bone metastases are uncommon. We describe three cases of bone metastases in patients with advanced GISTs: two women (82 and 54 years of age), and one man (62 years of age). Bones metastases involved the spine, pelvis and ribs in one patient, multiple vertebral bodies and pelvis in one, and the spine and iliac wings in the third case. The lesions presented a lytic pattern in all cases. Two patients presented with multiple bone metastases at the time of initial diagnosis and one patient after seven years during the follow-up period. This report describes the diagnosis and treatment of the lesions and may help clinicians to manage bones metastases in GIST patients.
2011
Three cases of bone metastases in patients with gastrointestinal stromal tumors / V. Di Scioscio; L. Greco; M. Pallotti; M. Pantaleo; A. Maleddu; M. Nannini; A. Bazzocchi; M. Di Battista; A. Mandrioli; C. Lolli; M. Saponara; G. Garzillo; G. Biasco; M. Zompatori. - In: RARE TUMORS. - ISSN 2036-3605. - ELETTRONICO. - 3:2(2011), pp. e17.51-e17.53. [10.4081/rt.2011.e17]
V. Di Scioscio; L. Greco; M. Pallotti; M. Pantaleo; A. Maleddu; M. Nannini; A. Bazzocchi; M. Di Battista; A. Mandrioli; C. Lolli; M. Saponara; G. Garzillo; G. Biasco; M. Zompatori
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/102346
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 19
  • Scopus 26
  • ???jsp.display-item.citation.isi??? ND
social impact