Cimetidine (cim) is a drud largely used in medicine for its blocking effect on histamine H2 receptors. Its pharmacological action appeared related to the interaction with metal ion leading to the formation of metallo-complexes; for this purpose 4 cim-metal systems were studied by the mole ratio method. A further spectrophotometric analysis was performed in order to obtain reliable spectra of 2:1 and 1:1 cim-metal complexes. The UV-vis spectra of all cim-metal complexes exhibit one band at 220 nm, whose wavelength does not shift upon complexation with cim. Nevertheless, they changes in intensity, supporting the existence of both 1:2 and 1:1 metal complexes. Moreover, the spectra of the Cu(II) complex clearly shows the formation of two new bands at about 332 and 368 nm and a third weak, broad absorption at 619 nm. The effect of the counter-ion was considered too, extending the measurements to chlorides, nitrates and perchlorates of the selected cations. The analysis of the spectrophotometric data suggests that Cu(II)-cim complexes are the most stable and therefore confirms the results already obtained by SERS (Surface Enhanced Raman Spectroscopy) technique on the same systems.
Spectrophotometric study on the interaction of cimetidine with Co(II), Cu(II), Ni(II) and Zn(II) metal ions.
DI FOGGIA, MICHELE;BONORA, SERGIO;
2010
Abstract
Cimetidine (cim) is a drud largely used in medicine for its blocking effect on histamine H2 receptors. Its pharmacological action appeared related to the interaction with metal ion leading to the formation of metallo-complexes; for this purpose 4 cim-metal systems were studied by the mole ratio method. A further spectrophotometric analysis was performed in order to obtain reliable spectra of 2:1 and 1:1 cim-metal complexes. The UV-vis spectra of all cim-metal complexes exhibit one band at 220 nm, whose wavelength does not shift upon complexation with cim. Nevertheless, they changes in intensity, supporting the existence of both 1:2 and 1:1 metal complexes. Moreover, the spectra of the Cu(II) complex clearly shows the formation of two new bands at about 332 and 368 nm and a third weak, broad absorption at 619 nm. The effect of the counter-ion was considered too, extending the measurements to chlorides, nitrates and perchlorates of the selected cations. The analysis of the spectrophotometric data suggests that Cu(II)-cim complexes are the most stable and therefore confirms the results already obtained by SERS (Surface Enhanced Raman Spectroscopy) technique on the same systems.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
