MANCINI, MANUELA
MANCINI, MANUELA
DIPARTIMENTO DI MEDICINA SPECIALISTICA, DIAGNOSTICA E SPERIMENTALE (attivo dal 28/10/2011 al 31/12/2022)
Assegnisti
M. Mancini; Manuela Mancini; Mancini M; Mancini
14-3-3 Binding and Sumoylation Concur to the Down-Modulation of β-catenin Antagonist chibby 1 in Chronic Myeloid Leukemia
2015 Mancini, Manuela; Leo, Elisa; Takemaru, Ken-Ichi; Campi, Virginia; Castagnetti, Fausto; Soverini, Simona; De Benedittis, Caterina; Rosti, Gianantonio; Cavo, Michele; Santucci, Maria Alessandra; Martinelli, Giovanni
A calpain-cleaved fragment of β-catenin promotes BCRABL1+ cell survival evoked by autophagy induction in response to imatinib
2014 Manuela Mancini;Elisa Leo;Virginia Campi;Fausto Castagnetti;Luca Zazzeroni;Gabriele Gugliotta;Maria Alessandra Santucci;Giovanni Martinelli
A new class of dual SRC/ABL kinase inhibitors for the treatment of imatinib-resistant chronic myeloid leukemias
2007 Corradi V.; Mancini M.; Corrado P.; Barbieri E.; Santucci M.A.; Schenone S.; Botta M.
A simple prognostic scoring system for newly diagnosed cytogenetically normal acute myeloid leukemia: retrospective analysis of 530 patients.
2011 Malagola M; Skert C; Vignetti M; Piciocchi A; Martinelli G; Alimena G; Mecucci C; Testoni N; Iacobucci I; Clavio M; Gobbi M; Candoni A; Damiani D; Bocchia M; Lauria F; Zaccaria A; Mazza P; Visani G; Peli A; Colombi C; Cancelli V; Mancini M; Fo R; Martelli M; Cantore N; Raimondo FD; Petrini M; de Fabritiis P; Fioritoni G; Nobile F; Fabbiano F; Specchia G; Baccarani M; Coco FL; Amadori S; Mandelli F; Russo D.
Apoptotic death of Bcr-Abl-expressing myeloid progenitors in response to the m-Tor inhibitor RAD001 (Everolimus) is promoted by the nuclear import of c-Abl
2006 Mancini M.; Zuffa E.; Corrado P.; Brusa G.; Petta S.; Pagnotta E.; Santucci M.A.
BCR-ABL1-associated reduction of beta catenin antagonist Chibby1 in chronic myeloid leukemia.
2013 Leo E;Mancini M;Aluigi M;Luatti S;Castagnetti F;Testoni N;Soverini S;Santucci MA;Martinelli G
Best practices in chronic myeloid leukemia monitoring and management
2016 Soverini, S; De Benedittis, C; Mancini, M; Martinelli, G.
C6-Unsubstituted Pyrazolo[3,4-d]pyrimidines Are Dual Src/Abl Inhibitors Effective against Imatinib Mesylate Resistant Chronic Myeloid Leukemia Cell Lines.
2009 Santucci MA; Corradi V; Mancini M; Manetti F; Radi M; Schenone S; Botta M.
Case Report: A Novel Activating FLT3 Mutation in Acute Myeloid Leukemia
2021 Bruno S.; Bandini L.; Patuelli A.; Robustelli V.; Venturi C.; Mancini M.; Forte D.; De Santis S.; Monaldi C.; Grassi A.; Chiurumbolo G.; Paolini S.; Cristiano G.; Papayannidis C.; Sartor C.; Nanni J.; Ottaviani E.; Curti A.; Cavo M.; Soverini S.
Chibby 1: A new component of β-catenin-signaling in chronic myeloid leukemia
2017 Mancini, Manuela; Soverini, Simona; Gugliotta, Gabriele; Santucci, MARIA ALESSANDRA; Rosti, Gianantonio; Cavo, Michele; Martinelli, Giovanni; Castagnetti, Fausto
Chibby drives β catenin cytoplasmic accumulation leading to activation of the unfolded protein response in BCR-ABL1+ cells
2013 Manuela Mancini;Elisa Leo;Ken-Ichi Takemaru;Virginia Campi;Enrica Borsi;Fausto Castagnetti;Gabriele Gugliotta;Maria Alessandra Santucci;Giovanni Martinelli
Chronic myeloid leukemia: the paradigm of targeting oncogenic tyrosine kinase signaling and counteracting resistance for successful cancer therapy
2018 Soverini, Simona; Mancini, Manuela; Bavaro, Luana; Cavo, Michele; Martinelli, Giovanni
Clinical impact of low-burden BCR-ABL1 mutations detectable by amplicon deep sequencing in Philadelphia-positive acute lymphoblastic leukemia patients
2016 Soverini, S; De Benedittis, C; Papayannidis, C; Polakova, K Machova; Venturi, C; Russo, D; Bresciani, P; Iurlo, A; Mancini, M; Vitale, A; Chiaretti, S; Foà, R; Abruzzese, E; Sorà, F; Kohlmann, A; Haferlach, T; Baccarani, M; Cavo, M; Martinelli, G
CML-184 A Novel Droplet Digital PCR Strategy for Rapid and Sensitive Detection of BCR::ABL1 Kinase Domain Mutations Conferring Resistance to Second-Generation Tyrosine Kinase Inhibitors
2022 de Santis S.; Monaldi C.; Martelli M.; Mancini M.; Bruno S.; Castagnetti F.; Gugliotta G.; Polakova K.M.; Ernst T.; Maar D.; Corner A.; Cavo M.; Soverini S.
Combined Inhibition of Polo-like Kinase-1 and Wee1 as a New Therapeutic Strategy to Induce Apoptotic Cell Death in Neoplastic Mast Cells
2022 Mancini M.; Monaldi C.; De Santis S.; Rondoni M.; Papayannidis C.; Sartor C.; Curti A.; Bruno S.; Cavo M.; Soverini S.
Cyclin-dependent kinase 2 (Cdk2) activity at the G1 to S boundary has a role in the resistance of Chronic Myeloid Leukemia (CML) haematopoietic progenitors to the tyrosine kinase inhibitor STI571 (Imatinib)
2004 M. Mancini; G. Brusa; A. Calabrò; N. Calonghi; E. Pagnotta; M. Alessandra Santucci; L. Masotti
Cytoplasmatic compartmentalization by Bcr-Abl promotes TET2 loss-of-function in chronic myeloid leukemia
2012 Manuela Mancini;Nevena Veljkovic;Elisa Leo;Michela Aluigi;Enrica Borsi;Chiara Galloni;Ilaria Iacobucci;Enza Barbieri;Maria Alessandra Santucci
Deep sequencing of the BCR-ABL kinase domain reveals a frequency of 35INS insertion/truncation higher than expected
2013 De Benedittis C, Soverini S, Machova Polakova K, Brouckova A, Castagnetti F, Gugliotta G, Palandri F, Papayannidis C, Klamova H, Bresciani P, Coluccio V, Salvucci M, Tiribelli M, Binotto G, Intermesoli T, Iacobucci I, Venturi C, Luppi M, Ottaviani E, MT Bochicchio, Cattina F, Mancini M, Elisa L, Haferlach T, Kohlmann A, Russo D, Rosti G, Baccarani M, Cavo M, Martinelli G.
Deletionsof the derivative chromosome 9 do not influence the response and the outcomeof chronic myeloid leukemia in early chronic phase treated with imatinibmesylate: GIMEMA CML Working Party analysis
2010 Castagnetti F; Testoni N;Luatti S; Marzocchi G; Mancini M; Kerim S; Giugliano E; Albano F; Cuneo A;Abruzzese E; Martino B; Palandri F; Amabile M; Iacobucci I; Alimena G; Pane F; Martinelli G; Saglio G; Baccarani M; Rosti G
Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents.
2008 Radi M; Crespan E; Botta G; Falchi F; Maga G; Manetti F; Corradi V; Mancini M; Santucci MA; Schenone S; Botta M.
| Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
|---|---|---|---|---|---|---|
| 14-3-3 Binding and Sumoylation Concur to the Down-Modulation of β-catenin Antagonist chibby 1 in Chronic Myeloid Leukemia | Mancini, Manuela; Leo, Elisa; Takemaru, Ken-Ichi; Campi, Virginia; Castagnetti, Fausto; Soverini,... Simona; De Benedittis, Caterina; Rosti, Gianantonio; Cavo, Michele; Santucci, Maria Alessandra; Martinelli, Giovanni | 2015-01-01 | PLOS ONE | - | 1.01 Articolo in rivista | Mancini_PONE_2015.pdf; pone.0131074.s001.pdf; pone.0131074.s002.pdf; pone.0131074.s003.pdf; pone.0131074.s004.pdf; pone.0131074.s004.pdf |
| A calpain-cleaved fragment of β-catenin promotes BCRABL1+ cell survival evoked by autophagy induction in response to imatinib | Manuela Mancini;Elisa Leo;Virginia Campi;Fausto Castagnetti;Luca Zazzeroni;Gabriele Gugliotta;Mar...ia Alessandra Santucci;Giovanni Martinelli | 2014-01-01 | CELLULAR SIGNALLING | - | 1.01 Articolo in rivista | - |
| A new class of dual SRC/ABL kinase inhibitors for the treatment of imatinib-resistant chronic myeloid leukemias | Corradi V.; Mancini M.; Corrado P.; Barbieri E.; Santucci M.A.; Schenone S.; Botta M. | 2007-01-01 | - | s.n | 4.02 Riassunto (Abstract) | - |
| A simple prognostic scoring system for newly diagnosed cytogenetically normal acute myeloid leukemia: retrospective analysis of 530 patients. | Malagola M; Skert C; Vignetti M; Piciocchi A; Martinelli G; Alimena G; Mecucci C; Testoni N; Iaco...bucci I; Clavio M; Gobbi M; Candoni A; Damiani D; Bocchia M; Lauria F; Zaccaria A; Mazza P; Visani G; Peli A; Colombi C; Cancelli V; Mancini M; Fo R; Martelli M; Cantore N; Raimondo FD; Petrini M; de Fabritiis P; Fioritoni G; Nobile F; Fabbiano F; Specchia G; Baccarani M; Coco FL; Amadori S; Mandelli F; Russo D. | 2011-01-01 | LEUKEMIA & LYMPHOMA | - | 1.01 Articolo in rivista | - |
| Apoptotic death of Bcr-Abl-expressing myeloid progenitors in response to the m-Tor inhibitor RAD001 (Everolimus) is promoted by the nuclear import of c-Abl | Mancini M.; Zuffa E.; Corrado P.; Brusa G.; Petta S.; Pagnotta E.; Santucci M.A. | 2006-01-01 | - | s.n | 4.02 Riassunto (Abstract) | - |
| BCR-ABL1-associated reduction of beta catenin antagonist Chibby1 in chronic myeloid leukemia. | Leo E;Mancini M;Aluigi M;Luatti S;Castagnetti F;Testoni N;Soverini S;Santucci MA;Martinelli G | 2013-01-01 | PLOS ONE | - | 1.01 Articolo in rivista | Leo et al_PONE2013.pdf |
| Best practices in chronic myeloid leukemia monitoring and management | Soverini, S; De Benedittis, C; Mancini, M; Martinelli, G. | 2016-01-01 | THE ONCOLOGIST | - | 1.01 Articolo in rivista | - |
| C6-Unsubstituted Pyrazolo[3,4-d]pyrimidines Are Dual Src/Abl Inhibitors Effective against Imatinib Mesylate Resistant Chronic Myeloid Leukemia Cell Lines. | Santucci MA; Corradi V; Mancini M; Manetti F; Radi M; Schenone S; Botta M. | 2009-01-01 | CHEMMEDCHEM | - | 1.01 Articolo in rivista | - |
| Case Report: A Novel Activating FLT3 Mutation in Acute Myeloid Leukemia | Bruno S.; Bandini L.; Patuelli A.; Robustelli V.; Venturi C.; Mancini M.; Forte D.; De Santis S.;... Monaldi C.; Grassi A.; Chiurumbolo G.; Paolini S.; Cristiano G.; Papayannidis C.; Sartor C.; Nanni J.; Ottaviani E.; Curti A.; Cavo M.; Soverini S. | 2021-01-01 | FRONTIERS IN ONCOLOGY | - | 1.01 Articolo in rivista | fonc-11-728613.pdf |
| Chibby 1: A new component of β-catenin-signaling in chronic myeloid leukemia | Mancini, Manuela; Soverini, Simona; Gugliotta, Gabriele; Santucci, MARIA ALESSANDRA; Rosti, Giana...ntonio; Cavo, Michele; Martinelli, Giovanni; Castagnetti, Fausto | 2017-01-01 | ONCOTARGET | - | 1.01 Articolo in rivista | - |
| Chibby drives β catenin cytoplasmic accumulation leading to activation of the unfolded protein response in BCR-ABL1+ cells | Manuela Mancini;Elisa Leo;Ken-Ichi Takemaru;Virginia Campi;Enrica Borsi;Fausto Castagnetti;Gabrie...le Gugliotta;Maria Alessandra Santucci;Giovanni Martinelli | 2013-01-01 | CELLULAR SIGNALLING | - | 1.01 Articolo in rivista | - |
| Chronic myeloid leukemia: the paradigm of targeting oncogenic tyrosine kinase signaling and counteracting resistance for successful cancer therapy | Soverini, Simona; Mancini, Manuela; Bavaro, Luana; Cavo, Michele; Martinelli, Giovanni | 2018-01-01 | MOLECULAR CANCER | - | 1.01 Articolo in rivista | document.pdf |
| Clinical impact of low-burden BCR-ABL1 mutations detectable by amplicon deep sequencing in Philadelphia-positive acute lymphoblastic leukemia patients | Soverini, S; De Benedittis, C; Papayannidis, C; Polakova, K Machova; Venturi, C; Russo, D; Bresci...ani, P; Iurlo, A; Mancini, M; Vitale, A; Chiaretti, S; Foà, R; Abruzzese, E; Sorà, F; Kohlmann, A; Haferlach, T; Baccarani, M; Cavo, M; Martinelli, G | 2016-01-01 | LEUKEMIA | - | 1.01 Articolo in rivista | - |
| CML-184 A Novel Droplet Digital PCR Strategy for Rapid and Sensitive Detection of BCR::ABL1 Kinase Domain Mutations Conferring Resistance to Second-Generation Tyrosine Kinase Inhibitors | de Santis S.; Monaldi C.; Martelli M.; Mancini M.; Bruno S.; Castagnetti F.; Gugliotta G.; Polako...va K.M.; Ernst T.; Maar D.; Corner A.; Cavo M.; Soverini S. | 2022-01-01 | CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | - | 1.01 Articolo in rivista | - |
| Combined Inhibition of Polo-like Kinase-1 and Wee1 as a New Therapeutic Strategy to Induce Apoptotic Cell Death in Neoplastic Mast Cells | Mancini M.; Monaldi C.; De Santis S.; Rondoni M.; Papayannidis C.; Sartor C.; Curti A.; Bruno S.;... Cavo M.; Soverini S. | 2022-01-01 | CANCERS | - | 1.01 Articolo in rivista | cancers-14-00738.pdf; cancers-14-00738-s001.zip |
| Cyclin-dependent kinase 2 (Cdk2) activity at the G1 to S boundary has a role in the resistance of Chronic Myeloid Leukemia (CML) haematopoietic progenitors to the tyrosine kinase inhibitor STI571 (Imatinib) | M. Mancini; G. Brusa; A. Calabrò; N. Calonghi; E. Pagnotta; M. Alessandra Santucci; L. Masotti | 2004-01-01 | - | Graphital | 4.01 Contributo in Atti di convegno | - |
| Cytoplasmatic compartmentalization by Bcr-Abl promotes TET2 loss-of-function in chronic myeloid leukemia | Manuela Mancini;Nevena Veljkovic;Elisa Leo;Michela Aluigi;Enrica Borsi;Chiara Galloni;Ilaria Iaco...bucci;Enza Barbieri;Maria Alessandra Santucci | 2012-01-01 | JOURNAL OF CELLULAR BIOCHEMISTRY | - | 1.01 Articolo in rivista | - |
| Deep sequencing of the BCR-ABL kinase domain reveals a frequency of 35INS insertion/truncation higher than expected | De Benedittis C, Soverini S, Machova Polakova K, Brouckova A, Castagnetti F, Gugliotta G, Palandr...i F, Papayannidis C, Klamova H, Bresciani P, Coluccio V, Salvucci M, Tiribelli M, Binotto G, Intermesoli T, Iacobucci I, Venturi C, Luppi M, Ottaviani E, MT Bochicchio, Cattina F, Mancini M, Elisa L, Haferlach T, Kohlmann A, Russo D, Rosti G, Baccarani M, Cavo M, Martinelli G. | 2013-01-01 | HAEMATOLOGICA | - | 1.06 Abstract in rivista | - |
| Deletionsof the derivative chromosome 9 do not influence the response and the outcomeof chronic myeloid leukemia in early chronic phase treated with imatinibmesylate: GIMEMA CML Working Party analysis |
Castagnetti F; Testoni N;Luatti S; Marzocchi G; Mancini M; Kerim S; Giugliano E; Albano F; Cuneo... A;Abruzzese E; Martino B; Palandri F; Amabile M; Iacobucci I; Alimena G; Pane F; Martinelli G; Saglio G; Baccarani M; Rosti G |
2010-01-01 | JOURNAL OF CLINICAL ONCOLOGY | - | 1.01 Articolo in rivista | - |
| Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents. | Radi M; Crespan E; Botta G; Falchi F; Maga G; Manetti F; Corradi V; Mancini M; Santucci MA; Schen...one S; Botta M. | 2008-01-01 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - | 1.01 Articolo in rivista | - |