DE SIMONE, ANGELA
DE SIMONE, ANGELA
DIPARTIMENTO DI SCIENZE PER LA QUALITA' DELLA VITA
Assegnisti
(±)- BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease
2021 Ismaili L.; Monnin J.; Etievant A.; Arribas R.L.; Viejo L.; Refouvelet B.; Soukup O.; Janockova J.; Hepnarova V.; Korabecny J.; Kucera T.; Jun D.; Andrys R.; Musilek K.; Baguet A.; Garcia-Frutos E.M.; De Simone A.; Andrisano V.; Bartolini M.; De Los Rios C.; Marco-Contelles J.; Haffen E.
- Application of an ESI-MS method enabling the discovery of new non-ATP competitive GSK-3beta inhibitors.
2016 Angela, De Simone; Andrea, Milelli; Marina, Naldi; Vincenza, Andrisano
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease
2015 Prati, Federica; De Simone, Angela; Armirotti, Andrea; Summa, Maria; Pizzirani, Daniela; Scarpelli, Rita; Bertozzi, Sine Mandrup; Perez, Daniel I.; Andrisano, Vincenza; Perez-Castillo, Ana; Monti, Barbara; Massenzio, Francesca; Polito, Letizia; Racchi, Marco; Sabatino, Piera; Bottegoni, Giovanni; Martinez, Ana; Cavalli, Andrea; Bolognesi, Maria L.
A multi-approach study for BACE-1 inhibitors characterization.
2010 Angela De Simone; F. Mancini; C. Bertucci; V. Andrisano
A multi-methodological approach for the investigation of β-Amyloid-CORMs interaction: an LC-ESI/MS and Circular Dichroism study.
2018 de simone a, naldi m, tedesco d, bartolini m, andrisano v
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors
2019 Perez-Areales F.J.; Turcu A.L.; Barniol-Xicota M.; Pont C.; Pivetta D.; Espargaro A.; Bartolini M.; De Simone A.; Andrisano V.; Perez B.; Sabate R.; Sureda F.X.; Vazquez S.; Munoz-Torrero D.
A patent review of butyrylcholinesterase inhibitors and reactivators 2010–2017
2018 Andrisano, Vincenza*; Naldi, Marina; De Simone, Angela; Bartolini, Manuela
A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: structure-based design, synthesis, and biological evaluation
2012 G. P. Chiriano; A. De Simone; F. Mancini; D. I. Perez; A. Cavalli; M. L. Bolognesi; G. Legname; A. Martinez; V. Andrisano; P. Carloni; M. Roberti
Advanced analytical methodologies in Alzheimer's disease drug discovery
2020 De Simone A.; Naldi M.; Tedesco D.; Bartolini M.; Davani L.; Andrisano V.
Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease
2019 Hulcova D.; Marikova J.; Korabecny J.; Hostalkova A.; Jun D.; Kunes J.; Chlebek J.; Opletal L.; De Simone A.; Novakova L.; Andrisano V.; Ruzicka A.; Cahlikova L.
Amyloid beta-Peptide 25-35 Self Assembly and Its Inhibition: A Model Undecapeptide System to Gain Atomistic and Secondary Structure Details of the Alzheimer's Disease Process and Treatment
2012 Naldi M.; Fiori J.; Pistolozzi M.; Drake A.F.; Bertucci C.; Wu R.; Mlynarczyk K.; Filipek S.; De Simone A.; Andrisano V.
An Advanced Multiple Receptor Conformations Virtual Ligand Screening Protocol for the Identification of Novel BACE-1 Inhibitors
2011 Kacker, Puneet; Masetti, Matteo; De Simone, Angela; Bottegoni, Giovanni; Cavalli, Andrea
An immobilized enzyme reactor based on human recombinant betasecretase (hrBACE-1-IMER) for the fast processing of substrates and screening of inhibitors
2012 Chlebek, Jakub; De Simone, Angela; Mancini, Francesca; Andrisano, Vincenza
Analytical approaches in Alzheimer’s disease Drug Discovery
2015 De Simone, Angela; Bartolini, Manuela; Fiori, Jessica; D’Urzo, Annalisa; Naldi, Marina.; Andrisano, Vincenza
Analytical characterization of fruits waste for their valorization as sources of bioactive compounds.
2023 Cristina Terenzi, Gabriela Alejandra Bermudez Leon, Lara Davani, Serena Montanari, Francesca Medri, Angela De Simone, Vincenza Andrisano
Application of an ESI-MS method enabling the discovery of new non-ATP competitive GSK-3beta inhibitors.
2016 De Simone, A; Milelli, A; Naldi, M; Andrisano, V.
Application of an ESI-QTOF method for the detailed characterization of GSK-3β inhibitors
2017 De Simone, Angela; Fiori, Jessica; Naldi, Marina; D'Urzo, Annalisa; Tumiatti, Vincenzo; Milelli, Andrea; Andrisano, Vincenza
Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets
2016 Chlebek, Jakub; De Simone, Angela; Hoš͗álková, Anna; Opletal, Lubomír; Pérez, Concepción; Pérez, Daniel I.; Havlíková, Lucie; Cahlíková, Lucie; Andrisano, Vincenza
Application of ESI-MS method for detailed characterization of GSK-3β inhibitors by monitoring GSM peptide phosphorylation.Angelini Farmaceutici.
2016 De Simone, A; Naldi, M; Milelli, A; Andrisano, V
Aß42 peptide toxicity on neuronal cells: a lipidomic study in view of Alzheimer’s Disease drug discovery
2021 Lara Davani, Xiaoqing Fu, Angela De Simone, Peng Li, Serena Montanari, Michael Lämmerhofer, Vincenza Andrisano
| Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
|---|---|---|---|---|---|---|
| (±)- BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease | Ismaili L.; Monnin J.; Etievant A.; Arribas R.L.; Viejo L.; Refouvelet B.; Soukup O.; Janockova J....; Hepnarova V.; Korabecny J.; Kucera T.; Jun D.; Andrys R.; Musilek K.; Baguet A.; Garcia-Frutos E.M.; De Simone A.; Andrisano V.; Bartolini M.; De Los Rios C.; Marco-Contelles J.; Haffen E. | 2021-01-01 | ACS CHEMICAL NEUROSCIENCE | - | 1.01 Articolo in rivista | - |
| - Application of an ESI-MS method enabling the discovery of new non-ATP competitive GSK-3beta inhibitors. | Angela, De Simone; Andrea, Milelli; Marina, Naldi; Vincenza, Andrisano | 2016-01-01 | - | - | 4.03 Poster | - |
| 3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease | Prati, Federica; De Simone, Angela; Armirotti, Andrea; Summa, Maria; Pizzirani, Daniela; Scarpell...i, Rita; Bertozzi, Sine Mandrup; Perez, Daniel I.; Andrisano, Vincenza; Perez-Castillo, Ana; Monti, Barbara; Massenzio, Francesca; Polito, Letizia; Racchi, Marco; Sabatino, Piera; Bottegoni, Giovanni; Martinez, Ana; Cavalli, Andrea; Bolognesi, Maria L. | 2015-01-01 | ACS CHEMICAL NEUROSCIENCE | - | 1.01 Articolo in rivista | accepted11585-546374.pdf |
| A multi-approach study for BACE-1 inhibitors characterization. | Angela De Simone; F. Mancini; C. Bertucci; V. Andrisano | 2010-01-01 | - | - | 4.01 Contributo in Atti di convegno | - |
| A multi-methodological approach for the investigation of β-Amyloid-CORMs interaction: an LC-ESI/MS and Circular Dichroism study. | de simone a, naldi m, tedesco d, bartolini m, andrisano v | 2018-01-01 | - | - | 4.01 Contributo in Atti di convegno | - |
| A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors | Perez-Areales F.J.; Turcu A.L.; Barniol-Xicota M.; Pont C.; Pivetta D.; Espargaro A.; Bartolini M....; De Simone A.; Andrisano V.; Perez B.; Sabate R.; Sureda F.X.; Vazquez S.; Munoz-Torrero D. | 2019-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| A patent review of butyrylcholinesterase inhibitors and reactivators 2010–2017 | Andrisano, Vincenza*; Naldi, Marina; De Simone, Angela; Bartolini, Manuela | 2018-01-01 | EXPERT OPINION ON THERAPEUTIC PATENTS | - | 1.01 Articolo in rivista | - |
| A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: structure-based design, synthesis, and biological evaluation | G. P. Chiriano; A. De Simone; F. Mancini; D. I. Perez; A. Cavalli; M. L. Bolognesi; G. Legname; A.... Martinez; V. Andrisano; P. Carloni; M. Roberti | 2012-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Advanced analytical methodologies in Alzheimer's disease drug discovery | De Simone A.; Naldi M.; Tedesco D.; Bartolini M.; Davani L.; Andrisano V. | 2020-01-01 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | - | 1.01 Articolo in rivista | - |
| Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease | Hulcova D.; Marikova J.; Korabecny J.; Hostalkova A.; Jun D.; Kunes J.; Chlebek J.; Opletal L.; D...e Simone A.; Novakova L.; Andrisano V.; Ruzicka A.; Cahlikova L. | 2019-01-01 | PHYTOCHEMISTRY | - | 1.01 Articolo in rivista | - |
| Amyloid beta-Peptide 25-35 Self Assembly and Its Inhibition: A Model Undecapeptide System to Gain Atomistic and Secondary Structure Details of the Alzheimer's Disease Process and Treatment | Naldi M.; Fiori J.; Pistolozzi M.; Drake A.F.; Bertucci C.; Wu R.; Mlynarczyk K.; Filipek S.; De ...Simone A.; Andrisano V. | 2012-01-01 | ACS CHEMICAL NEUROSCIENCE | - | 1.01 Articolo in rivista | - |
| An Advanced Multiple Receptor Conformations Virtual Ligand Screening Protocol for the Identification of Novel BACE-1 Inhibitors | Kacker, Puneet; Masetti, Matteo; De Simone, Angela; Bottegoni, Giovanni; Cavalli, Andrea | 2011-01-01 | - | - | 4.03 Poster | - |
| An immobilized enzyme reactor based on human recombinant betasecretase (hrBACE-1-IMER) for the fast processing of substrates and screening of inhibitors | Chlebek, Jakub; De Simone, Angela; Mancini, Francesca; Andrisano, Vincenza | 2012-01-01 | - | - | 4.03 Poster | - |
| Analytical approaches in Alzheimer’s disease Drug Discovery | De Simone, Angela; Bartolini, Manuela; Fiori, Jessica; D’Urzo, Annalisa; Naldi, Marina.; Andrisan...o, Vincenza | 2015-01-01 | - | - | 4.01 Contributo in Atti di convegno | - |
| Analytical characterization of fruits waste for their valorization as sources of bioactive compounds. | Cristina Terenzi, Gabriela Alejandra Bermudez Leon, Lara Davani, Serena Montanari, Francesca Medr...i, Angela De Simone, Vincenza Andrisano | 2023-01-01 | - | - | 4.03 Poster | - |
| Application of an ESI-MS method enabling the discovery of new non-ATP competitive GSK-3beta inhibitors. | De Simone, A; Milelli, A; Naldi, M; Andrisano, V. | 2016-01-01 | - | - | 4.03 Poster | - |
| Application of an ESI-QTOF method for the detailed characterization of GSK-3β inhibitors | De Simone, Angela; Fiori, Jessica; Naldi, Marina; D'Urzo, Annalisa; Tumiatti, Vincenzo; Milelli, ...Andrea; Andrisano, Vincenza | 2017-01-01 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | - | 1.01 Articolo in rivista | - |
| Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets | Chlebek, Jakub; De Simone, Angela; Hoš͗álková, Anna; Opletal, Lubomír; Pérez, Concepción; Pérez, ...Daniel I.; Havlíková, Lucie; Cahlíková, Lucie; Andrisano, Vincenza | 2016-01-01 | FITOTERAPIA | - | 1.01 Articolo in rivista | - |
| Application of ESI-MS method for detailed characterization of GSK-3β inhibitors by monitoring GSM peptide phosphorylation.Angelini Farmaceutici. | De Simone, A; Naldi, M; Milelli, A; Andrisano, V | 2016-01-01 | - | - | 4.01 Contributo in Atti di convegno | - |
| Aß42 peptide toxicity on neuronal cells: a lipidomic study in view of Alzheimer’s Disease drug discovery | Lara Davani, Xiaoqing Fu, Angela De Simone, Peng Li, Serena Montanari, Michael Lämmerhofer, Vince...nza Andrisano | 2021-01-01 | - | - | 4.03 Poster | - |