Sfoglia per Autore
The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation
2007 Follo, Matilde Y.; Mongiorgi, Sara; Bosi, Costanza; Cappellini, Alessandra; Finelli, Carlo; Chiarini, Francesca; Papa, Veronica; Libra, Massimo; Martinelli, Giovanni; Cocco, Lucio; Martelli, Alberto M.
Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin module for acute myelogenous leukemia therapy: from bench to bedside.
2007 Martelli AM; Tazzari PL; Evangelisti C; Chiarini F; Blalock WL; Billi AM; Manzoli L; McCubrey JA; Cocco L
Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy
2008 McCubrey J.A.; Sokolosky M.L.; Lehmann B.D.; Taylor J.R.; Navolanic P.M.; Chappell W.H.; Abrams S.L.; Stadelman K.M.; Wong E.W.; Misaghian N.; Horn S.; Bäsecke J.; Libra M.; Stivala F.; Ligresti G.; Tafuri A.; Milella M.; Zarzycki M.; Dzugaj A.; Chiarini F.; Evangelisti C.; Martelli A.M.; Terrian D.M.; Franklin R.A.; Steelman L.S.
Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor perifosine in acute myeloid leukemia cells.
2008 Tazzari P.L.; Tabellini G.; Ricci F.; Papa V.; Bortul R.; Chiarini F.; Evangelisti C.; Martinelli G.; Bontadini A.; Cocco L.; McCubrey J.A.; Martelli A.M.
Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells
2008 V. Papa; P.L. Tazzari; F. Chiarini; A. Cappellini; F. Ricci; A.M. Billi; C. Evangelisti; E. Ottaviani; G. Martinelli; N. Testoni; J.A. McCubrey; A.M. Martelli
Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-ami ne (A443654) in T-cell acute lymphoblastic leukemia.
2008 Falà F; Blalock WL; Tazzari PL; Cappellini A; Chiarini F; Martinelli G; Tafuri A; McCubrey JA; Cocco L; Martelli AM
The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resisten human T-acute leukemia cells by a JNK-dependent mechanism
2008 Chiarini F.; Del Sole M.; Mongiorgi S.; Gaboardi G.C.; Cappellini A.; Mantovani I.; Follo M.Y.; McCubrey J.A.; Martelli A.M.
Involvement of nuclear PLC{beta}1 in lamin B1 phosphorylation and G2/M cell cycle progression.
2009 Fiume R; Ramazzotti G; Teti G; Chiarini F; Faenza I; Mazzotti G; Billi AM; Cocco L
Toxicity of antimony trioxide nanoparticles on human hematopoietic progenitor cells and comparison to cell lines.
2009 Bregoli L; Chiarini F; Gambarelli A; Sighinolfi G; Gatti AM; Santi P; Martelli AM; Cocco L.
Effect of Erythropoietin Treatment on Lipid Signalling Pathways in Low-Risk MDS Patients.
2009 Matilde Y Follo; Sara Mongiorgi; Cristina Clissa; Francesca Chiarini; Stefania Paolini; Michele Baccarani; Giovanni Martinelli; Lucia Manzoli; Alberto M. Martelli; Carlo Finelli; Lucio Cocco
The cyclin-dependent kinase inhibitor roscovitine and the nucleoside analog sangivamycin induce apoptosis in caspase-3 deficient breast cancer cells independent of caspase mediated P-glycoprotein cleavage
2009 A. Cappellini; F. Chiarini; A. Ognibene; J.A. McCubrey; A.M. Martelli
Targeting the phosphatidylinositol 3-kinase/Akt/mTOR signaling network in acute myelogenous leukaemia.
2009 A.M. Martelli; C. Evangelisti; F. Chiarini; C. Grimaldi; L. Manzoli; J.A. McCubrey.
Dual inhibition of class IA phoshatidylinositol 3-kinase and mTOR as a new therapeutic option for T-cell acute lymphoblastic leukemia.
2009 F. Chiarini; F. Falà; P. L. Tazzari; F. Ricci; A. Astolfi; A. Pession; P. Pagliaro; J.A. McCubrey; A.M. Martelli.
Reduction of phosphoinositide-phospholipase C beta1 methylation predicts the responsiveness to azacitidine in high-risk MDS.
2009 Follo MY; Finelli C; Mongiorgi S; Clissa C; Bosi C; Testoni N; Chiarini F; Ramazzotti G; Baccarani M; Martelli AM; Manzoli L; Martinelli G; Cocco L
The phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin signaling network and the control of normal myelopoiesis
2010 Martelli AM; Chiarini F; Evangelisti C; Grimaldi C; Ognibene A; Manzoli L; Billi AM; McCubrey JA
Erucylphosphohomocholine, the first intravenously applicable alkylphosphocholine, is cytotoxic to acute myelogenous leukemia cells through JNK- and PP2A-dependent mechanisms.
2010 A.M. Martelli; V. Papa; P.L. Tazzari; F. Ricci; C. Evangelisti; F. Chiarini; C. Grimaldi; A. Cappellini; G. Martinelli; E. Ottaviani; P. Pagliaro; S. Horn; J. Bäsecke; L.H. Lindner; H. Eibl; J.A. McCubrey.
The Emerging Role of the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin Signaling Network in Cancer Stem Cell Biology.
2010 A.M. Martelli; C. Evangelisti; F. Chiarini; C. Grimaldi; J.A. McCubrey.
Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235, against T-cell acute lymphoblastic leukemia.
2010 F. Chiarini; C. Grimaldi; F. Ricci; P. L. Tazzari; C.Evangelisti; A. Ognibene; M.Battistelli; E. Falcieri; F. Melchionda; A. Pession; P. Pagliaro; J.A. McCubrey; A.M. Martelli.
The emerging role of the phosphatidylinositol 3-kinase/Akt/mTOR signaling network in normal myelopoieis and leukemogenesis.
2010 A.M. Martelli; C. Evangelisti; F. Chiarini; C. Grimaldi; A. Cappellini; A. Ognibene; J.A. McCubrey.
The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients
2010 A.M. Martelli; C. Evangelisti; F. Chiarini; J. A. McCubrey
| Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
|---|---|---|---|---|---|---|
| The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation | Follo, Matilde Y.; Mongiorgi, Sara; Bosi, Costanza; Cappellini, Alessandra; Finelli, Carlo; Chiar...ini, Francesca; Papa, Veronica; Libra, Massimo; Martinelli, Giovanni; Cocco, Lucio; Martelli, Alberto M. | 2007-01-01 | CANCER RESEARCH | - | 1.01 Articolo in rivista | - |
| Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin module for acute myelogenous leukemia therapy: from bench to bedside. |
Martelli AM; Tazzari PL; Evangelisti C; Chiarini F; Blalock WL; Billi AM; Manzoli L; McCubrey JA...; Cocco L |
2007-01-01 | CURRENT MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy | McCubrey J.A.; Sokolosky M.L.; Lehmann B.D.; Taylor J.R.; Navolanic P.M.; Chappell W.H.; Abrams S....L.; Stadelman K.M.; Wong E.W.; Misaghian N.; Horn S.; Bäsecke J.; Libra M.; Stivala F.; Ligresti G.; Tafuri A.; Milella M.; Zarzycki M.; Dzugaj A.; Chiarini F.; Evangelisti C.; Martelli A.M.; Terrian D.M.; Franklin R.A.; Steelman L.S. | 2008-01-01 | - | Elsevier Ltd. | 2.01 Capitolo / saggio in libro | - |
| Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor perifosine in acute myeloid leukemia cells. | Tazzari P.L.; Tabellini G.; Ricci F.; Papa V.; Bortul R.; Chiarini F.; Evangelisti C.; Martinelli... G.; Bontadini A.; Cocco L.; McCubrey J.A.; Martelli A.M. | 2008-01-01 | CANCER RESEARCH | - | 1.01 Articolo in rivista | - |
| Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells | V. Papa; P.L. Tazzari; F. Chiarini; A. Cappellini; F. Ricci; A.M. Billi; C. Evangelisti; E. Ottav...iani; G. Martinelli; N. Testoni; J.A. McCubrey; A.M. Martelli | 2008-01-01 | LEUKEMIA | - | 1.01 Articolo in rivista | - |
| Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-ami ne (A443654) in T-cell acute lymphoblastic leukemia. | Falà F; Blalock WL; Tazzari PL; Cappellini A; Chiarini F; Martinelli G; Tafuri A; McCubrey JA; Co...cco L; Martelli AM | 2008-01-01 | MOLECULAR PHARMACOLOGY | - | 1.01 Articolo in rivista | - |
| The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resisten human T-acute leukemia cells by a JNK-dependent mechanism | Chiarini F.; Del Sole M.; Mongiorgi S.; Gaboardi G.C.; Cappellini A.; Mantovani I.; Follo M.Y.; M...cCubrey J.A.; Martelli A.M. | 2008-01-01 | LEUKEMIA | - | 1.01 Articolo in rivista | - |
| Involvement of nuclear PLC{beta}1 in lamin B1 phosphorylation and G2/M cell cycle progression. |
Fiume R; Ramazzotti G; Teti G; Chiarini F; Faenza I; Mazzotti G; Billi AM; Cocco L |
2009-01-01 | THE FASEB JOURNAL | - | 1.01 Articolo in rivista | - |
| Toxicity of antimony trioxide nanoparticles on human hematopoietic progenitor cells and comparison to cell lines. | Bregoli L; Chiarini F; Gambarelli A; Sighinolfi G; Gatti AM; Santi P; Martelli AM; Cocco L. | 2009-01-01 | TOXICOLOGY | - | 1.01 Articolo in rivista | - |
| Effect of Erythropoietin Treatment on Lipid Signalling Pathways in Low-Risk MDS Patients. | Matilde Y Follo; Sara Mongiorgi; Cristina Clissa; Francesca Chiarini; Stefania Paolini; Michele B...accarani; Giovanni Martinelli; Lucia Manzoli; Alberto M. Martelli; Carlo Finelli; Lucio Cocco | 2009-01-01 | BLOOD | - | 4.01 Contributo in Atti di convegno | - |
| The cyclin-dependent kinase inhibitor roscovitine and the nucleoside analog sangivamycin induce apoptosis in caspase-3 deficient breast cancer cells independent of caspase mediated P-glycoprotein cleavage | A. Cappellini; F. Chiarini; A. Ognibene; J.A. McCubrey; A.M. Martelli | 2009-01-01 | CELL CYCLE | - | 1.01 Articolo in rivista | - |
| Targeting the phosphatidylinositol 3-kinase/Akt/mTOR signaling network in acute myelogenous leukaemia. | A.M. Martelli; C. Evangelisti; F. Chiarini; C. Grimaldi; L. Manzoli; J.A. McCubrey. | 2009-01-01 | EXPERT OPINION ON INVESTIGATIONAL DRUGS | - | 1.01 Articolo in rivista | - |
| Dual inhibition of class IA phoshatidylinositol 3-kinase and mTOR as a new therapeutic option for T-cell acute lymphoblastic leukemia. | F. Chiarini; F. Falà; P. L. Tazzari; F. Ricci; A. Astolfi; A. Pession; P. Pagliaro; J.A. McCubrey...; A.M. Martelli. | 2009-01-01 | CANCER RESEARCH | - | 1.01 Articolo in rivista | - |
| Reduction of phosphoinositide-phospholipase C beta1 methylation predicts the responsiveness to azacitidine in high-risk MDS. |
Follo MY; Finelli C; Mongiorgi S; Clissa C; Bosi C; Testoni N; Chiarini F; Ramazzotti G; Baccara...ni M; Martelli AM; Manzoli L; Martinelli G; Cocco L |
2009-01-01 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - | 1.01 Articolo in rivista | - |
| The phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin signaling network and the control of normal myelopoiesis | Martelli AM; Chiarini F; Evangelisti C; Grimaldi C; Ognibene A; Manzoli L; Billi AM; McCubrey JA | 2010-01-01 | HISTOLOGY AND HISTOPATHOLOGY | - | 1.01 Articolo in rivista | - |
| Erucylphosphohomocholine, the first intravenously applicable alkylphosphocholine, is cytotoxic to acute myelogenous leukemia cells through JNK- and PP2A-dependent mechanisms. | A.M. Martelli; V. Papa; P.L. Tazzari; F. Ricci; C. Evangelisti; F. Chiarini; C. Grimaldi; A. Capp...ellini; G. Martinelli; E. Ottaviani; P. Pagliaro; S. Horn; J. Bäsecke; L.H. Lindner; H. Eibl; J.A. McCubrey. | 2010-01-01 | LEUKEMIA | - | 1.01 Articolo in rivista | - |
| The Emerging Role of the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin Signaling Network in Cancer Stem Cell Biology. | A.M. Martelli; C. Evangelisti; F. Chiarini; C. Grimaldi; J.A. McCubrey. | 2010-01-01 | CANCERS | - | 1.01 Articolo in rivista | cancers-02-01576.pdf |
| Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235, against T-cell acute lymphoblastic leukemia. | F. Chiarini; C. Grimaldi; F. Ricci; P. L. Tazzari; C.Evangelisti; A. Ognibene; M.Battistelli; E. ...Falcieri; F. Melchionda; A. Pession; P. Pagliaro; J.A. McCubrey; A.M. Martelli. | 2010-01-01 | CANCER RESEARCH | - | 1.01 Articolo in rivista | - |
| The emerging role of the phosphatidylinositol 3-kinase/Akt/mTOR signaling network in normal myelopoieis and leukemogenesis. | A.M. Martelli; C. Evangelisti; F. Chiarini; C. Grimaldi; A. Cappellini; A. Ognibene; J.A. McCubrey. | 2010-01-01 | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | - | 1.01 Articolo in rivista | - |
| The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients | A.M. Martelli; C. Evangelisti; F. Chiarini; J. A. McCubrey | 2010-01-01 | ONCOTARGET | - | 1.01 Articolo in rivista | - |
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