Sfoglia per Autore
Multitarget Drug Design Strategy: Quinone–Tacrine Hybrids Designed To Block Amyloid-β Aggregation and To Exert Anticholinesterase and Antioxidant Effects
2014-01-01 Eugenie Nepovimova;Elisa Uliassi;Jan Korabecny;Luis Emiliano Peña-Altamira;Sarah Samez;Alessandro Pesaresi;Gregory E. Garcia;Manuela Bartolini;Vincenza Andrisano;Christian Bergamini;Romana Fato;Doriano Lamba;Marinella Roberti;Kamil Kuca;Barbara Monti;Maria Laura Bolognesi
Toward the Development of Dual-Targeted Glyceraldehyde-3-phosphate Dehydrogenase/Trypanothione Reductase Inhibitors againstTrypanosoma bruceiandTrypanosoma cruzi
2014-01-01 Federica Belluti;Elisa Uliassi;Giacomo Veronesi;Christian Bergamini;Marcel Kaiser;Reto Brun;Angelo Viola;Romana Fato;Paul A. M. Michels;R. Luise Krauth-Siegel;Andrea Cavalli;Maria Laura Bolognesi
Two diseases, one approach: multitarget drug discovery in Alzheimer's and neglected tropical diseases
2014-01-01 F. Prati;E. Uliassi;M. L. Bolognesi
TRIAZOLE DERIVATIVES AS P2Y14 RECEPTOR ANTAGONISTS
2015-01-01 Kenneth, A. Jacobson; Anna, Junker; Elisa, Uliassi; Evgeny, Kiselev
Design, synthesis, pharmacological characterization of a fluorescent agonist of the P2Y14 receptor
2015-01-01 Kiselev, Evgeny; Balasubramanian, Ramachandran; Uliassi, Elisa; Brown, Kyle A.; Trujillo, Kevin; Katritch, Vsevolod; Hammes, Eva; Stevens, Raymond C.; Harden, T. Kendall; Jacobson, Kenneth A.
The Hippo Pathway and YAP/TAZ-TEAD Protein-Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment
2015-01-01 Santucci, Matteo; Vignudelli, Tatiana; Ferrari, Stefania; Mor, Marco; Scalvini, Laura; Bolognesi, Maria Laura; Uliassi, Elisa; Costi, Maria Paola
TRIAZOLE DERIVATIVES AS P2Y14 RECEPTOR ANTAGONISTS
2016-01-01 Kenneth A. Jacobson; Anna Junker; Elisa Uliassi; Evgeny Kiselev
Triazole derivatives as P2Y14 receptor antagonists
2016-01-01 Kenneth A. Jacobson, Anna Junker, Elisa Uliassi, Evgeny Kiselev
Structure-Based Design of 3-(4-Aryl-1H-1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y14 Receptor Antagonists
2016-01-01 Junker, Anna; Balasubramanian, Ramachandran; Ciancetta, Antonella; Uliassi, Elisa; Kiselev, Evgeny; Martiriggiano, Chiara; Trujillo, Kevin; Mtchedlidze, Giorgi; Birdwell, Leah; Brown, Kyle A.; Harden, T. Kendall; Jacobson, Kenneth A
From Companion Diagnostics to Theranostics: A New Avenue for Alzheimer's Disease?
2016-01-01 Bolognesi, Maria Laura; Gandini, Annachiara; Prati, Federica; Uliassi, Elisa
Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease
2017-01-01 Jeřábek, Jakub; Uliassi, Elisa; Guidotti, Laura; Korábečný, Jan; Soukup, Ondřej; Sepsova, Vendula; Hrabinova, Martina; Kuča, Kamil; Bartolini, Manuela; Peña-Altamira, Luis Emiliano; Petralla, Sabrina; Monti, Barbara; Roberti, Marinella; Bolognesi, Maria Laura
Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity
2017-01-01 Uliassi, Elisa; Fiorani, Giulia; Krauth-Siegel, R. Luise; Bergamini, Christian; Fato, Romana; Bianchini, Giulia; Carlos Menéndez, J.; Molina, Maria Teresa; López-Montero, Eulogio; Falchi, Federico; Cavalli, Andrea; Gul, Sheraz; Kuzikov, Maria; Ellinger, Bernhard; Witt, Gesa; Moraes, Carolina B.; Freitas-Junior, Lucio H.; Borsari, Chiara; Costi, Maria Paola; Bolognesi, Maria Laura*
Medicinal Chemistry of Hybrids for Neurodegenerative Diseases
2017-01-01 Uliassi, Elisa*; Prati, Federica; Bongarzone, Salvatore; Bolognesi, Maria Laura
Drug Discovery Strategies for the Generation of Multitarget Ligands against Neglected Tropical Diseases
2017-01-01 Gandini, Annachiara; Prati, Federica; Uliassi, Elisa; Bolognesi, Maria L.
Molecular basis for covalent inhibition of glyceraldehyde-3-phosphate dehydrogenase by a 2-phenoxy-1,4-naphthoquinone small molecule
2017-01-01 Bruno, Stefano; Uliassi, Elisa; Zaffagnini, Mirko; Prati, Federica; Bergamini, Christian; Amorati, Riccardo; Paredi, Gianluca; Margiotta, Marilena; Conti, Paola; Costi, Maria Paola; Kaiser, Marcel; Cavalli, Andrea; Fato, Romana; Bolognesi, Maria Laura
Neuroregeneration versus neurodegeneration: Toward a paradigm shift in Alzheimer's disease drug discovery
2017-01-01 Uliassi, Elisa; Gandini, Annachiara; Perone, Rosaria Carmela; Bolognesi, Maria Laura*
Development of a Focused Library of Triazole-Linked Privileged-Structure-Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections
2018-01-01 Uliassi, Elisa; Piazzi, Lorna; Belluti, Federica; Mazzanti, Andrea; Kaiser, Marcel; Brun, Reto; Moraes, Carolina B.; Freitas-Junior, Lucio H.; Gul, Sheraz; Kuzikov, Maria; Ellinger, Bernhard; Borsari, Chiara; Costi, Maria Paola; Bolognesi, Maria Laura*
A perspective on multi-target drug discovery and design for complex diseases
2018-01-01 Ramsay, Rona R; Popovic-Nikolic, Marija R; Nikolic, Katarina; Uliassi, Elisa; Bolognesi, Maria Laura
Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform
2019-01-01 Carolina B. Moraes, Gesa Witt, Maria Kuzikov, Bernhard Ellinger, Theodora Calogeropoulou, Kyriakos C. Prousis, Stefano Mangani, Flavio Di Pisa, Giacomo Landi, Lucia Dello Iacono, Cecilia Pozzi, Lucio H. Freitas-Junior, Bruno dos Santos Pascoalino, Claudia P. Bertolacini, Birte Behrens, Oliver Keminer, Jennifer Leu, Markus Wolf, Jeanette Reinshagen, Anabela Cordeiro-da-Silva, Nuno Santarem, Alberto Venturelli, Stephen Wrigley, Deepa Karunakaran, Bethlehem Kebede, Ina Pöhner, Wolfgang Müller, Joanna Panecka-Hofman, Rebecca C. Wade, Martina Fenske, Joachim Clos, José María Alunda, María Jesús Corral, Elisa Uliassi, Maria Laura Bolognesi, Pasquale Linciano, Antonio Quotadamo, Stefania Ferrari, Matteo Santucci, Chiara Borsari, Maria Paola Costi, Sheraz Gul
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease
2019-01-01 Chalupova K.; Korabecny J.; Bartolini M.; Monti B.; Lamba D.; Caliandro R.; Pesaresi A.; Brazzolotto X.; Gastellier A.-J.; Nachon F.; Pejchal J.; Jarosova M.; Hepnarova V.; Jun D.; Hrabinova M.; Dolezal R.; Zdarova Karasova J.; Mzik M.; Kristofikova Z.; Misik J.; Muckova L.; Jost P.; Soukup O.; Benkova M.; Setnicka V.; Habartova L.; Chvojkova M.; Kleteckova L.; Vales K.; Mezeiova E.; Uliassi E.; Valis M.; Nepovimova E.; Bolognesi M.L.; Kuca K.
| Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
|---|---|---|---|---|---|---|
| Multitarget Drug Design Strategy: Quinone–Tacrine Hybrids Designed To Block Amyloid-β Aggregation and To Exert Anticholinesterase and Antioxidant Effects | Eugenie Nepovimova;Elisa Uliassi;Jan Korabecny;Luis Emiliano Peña-Altamira;Sarah Samez;Alessandro Pesaresi;Gregory E. Garcia;Manuela Bartolini;Vincenza Andrisano;Christian Bergamini;Romana Fato;Doriano Lamba;Marinella Roberti;Kamil Kuca;Barbara Monti;Maria Laura Bolognesi | 2014-01-01 | JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Toward the Development of Dual-Targeted Glyceraldehyde-3-phosphate Dehydrogenase/Trypanothione Reductase Inhibitors againstTrypanosoma bruceiandTrypanosoma cruzi | Federica Belluti;Elisa Uliassi;Giacomo Veronesi;Christian Bergamini;Marcel Kaiser;Reto Brun;Angelo Viola;Romana Fato;Paul A. M. Michels;R. Luise Krauth-Siegel;Andrea Cavalli;Maria Laura Bolognesi | 2014-01-01 | CHEMMEDCHEM | - | 1.01 Articolo in rivista | - |
| Two diseases, one approach: multitarget drug discovery in Alzheimer's and neglected tropical diseases | F. Prati;E. Uliassi;M. L. Bolognesi | 2014-01-01 | MEDCHEMCOMM | - | 1.01 Articolo in rivista | - |
| TRIAZOLE DERIVATIVES AS P2Y14 RECEPTOR ANTAGONISTS | Kenneth, A. Jacobson; Anna, Junker; Elisa, Uliassi; Evgeny, Kiselev | 2015-01-01 | - | - | 6.01 Brevetto | - |
| Design, synthesis, pharmacological characterization of a fluorescent agonist of the P2Y14 receptor | Kiselev, Evgeny; Balasubramanian, Ramachandran; Uliassi, Elisa; Brown, Kyle A.; Trujillo, Kevin; Katritch, Vsevolod; Hammes, Eva; Stevens, Raymond C.; Harden, T. Kendall; Jacobson, Kenneth A. | 2015-01-01 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - | 1.01 Articolo in rivista | - |
| The Hippo Pathway and YAP/TAZ-TEAD Protein-Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment | Santucci, Matteo; Vignudelli, Tatiana; Ferrari, Stefania; Mor, Marco; Scalvini, Laura; Bolognesi, Maria Laura; Uliassi, Elisa; Costi, Maria Paola | 2015-01-01 | JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| TRIAZOLE DERIVATIVES AS P2Y14 RECEPTOR ANTAGONISTS | Kenneth A. Jacobson; Anna Junker; Elisa Uliassi; Evgeny Kiselev | 2016-01-01 | - | - | 6.01 Brevetto | - |
| Triazole derivatives as P2Y14 receptor antagonists | Kenneth A. Jacobson, Anna Junker, Elisa Uliassi, Evgeny Kiselev | 2016-01-01 | - | - | 6.01 Brevetto | - |
| Structure-Based Design of 3-(4-Aryl-1H-1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y14 Receptor Antagonists | Junker, Anna; Balasubramanian, Ramachandran; Ciancetta, Antonella; Uliassi, Elisa; Kiselev, Evgeny; Martiriggiano, Chiara; Trujillo, Kevin; Mtchedlidze, Giorgi; Birdwell, Leah; Brown, Kyle A.; Harden, T. Kendall; Jacobson, Kenneth A | 2016-01-01 | JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| From Companion Diagnostics to Theranostics: A New Avenue for Alzheimer's Disease? | Bolognesi, Maria Laura; Gandini, Annachiara; Prati, Federica; Uliassi, Elisa | 2016-01-01 | JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease | Jeřábek, Jakub; Uliassi, Elisa; Guidotti, Laura; Korábečný, Jan; Soukup, Ondřej; Sepsova, Vendula; Hrabinova, Martina; Kuča, Kamil; Bartolini, Manuela; Peña-Altamira, Luis Emiliano; Petralla, Sabrina; Monti, Barbara; Roberti, Marinella; Bolognesi, Maria Laura | 2017-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity | Uliassi, Elisa; Fiorani, Giulia; Krauth-Siegel, R. Luise; Bergamini, Christian; Fato, Romana; Bianchini, Giulia; Carlos Menéndez, J.; Molina, Maria Teresa; López-Montero, Eulogio; Falchi, Federico; Cavalli, Andrea; Gul, Sheraz; Kuzikov, Maria; Ellinger, Bernhard; Witt, Gesa; Moraes, Carolina B.; Freitas-Junior, Lucio H.; Borsari, Chiara; Costi, Maria Paola; Bolognesi, Maria Laura* | 2017-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Medicinal Chemistry of Hybrids for Neurodegenerative Diseases | Uliassi, Elisa*; Prati, Federica; Bongarzone, Salvatore; Bolognesi, Maria Laura | 2017-01-01 | - | Elsevier Inc. | 2.01 Capitolo / saggio in libro | - |
| Drug Discovery Strategies for the Generation of Multitarget Ligands against Neglected Tropical Diseases | Gandini, Annachiara; Prati, Federica; Uliassi, Elisa; Bolognesi, Maria L. | 2017-01-01 | - | Wiley‐VCH Verlag GmbH & Co. KGaA | 2.01 Capitolo / saggio in libro | - |
| Molecular basis for covalent inhibition of glyceraldehyde-3-phosphate dehydrogenase by a 2-phenoxy-1,4-naphthoquinone small molecule | Bruno, Stefano; Uliassi, Elisa; Zaffagnini, Mirko; Prati, Federica; Bergamini, Christian; Amorati, Riccardo; Paredi, Gianluca; Margiotta, Marilena; Conti, Paola; Costi, Maria Paola; Kaiser, Marcel; Cavalli, Andrea; Fato, Romana; Bolognesi, Maria Laura | 2017-01-01 | CHEMICAL BIOLOGY & DRUG DESIGN | - | 1.01 Articolo in rivista | - |
| Neuroregeneration versus neurodegeneration: Toward a paradigm shift in Alzheimer's disease drug discovery | Uliassi, Elisa; Gandini, Annachiara; Perone, Rosaria Carmela; Bolognesi, Maria Laura* | 2017-01-01 | FUTURE MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Development of a Focused Library of Triazole-Linked Privileged-Structure-Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections | Uliassi, Elisa; Piazzi, Lorna; Belluti, Federica; Mazzanti, Andrea; Kaiser, Marcel; Brun, Reto; Moraes, Carolina B.; Freitas-Junior, Lucio H.; Gul, Sheraz; Kuzikov, Maria; Ellinger, Bernhard; Borsari, Chiara; Costi, Maria Paola; Bolognesi, Maria Laura* | 2018-01-01 | CHEMMEDCHEM | - | 1.01 Articolo in rivista | - |
| A perspective on multi-target drug discovery and design for complex diseases | Ramsay, Rona R; Popovic-Nikolic, Marija R; Nikolic, Katarina; Uliassi, Elisa; Bolognesi, Maria Laura | 2018-01-01 | CLINICAL AND TRANSLATIONAL MEDICINE | - | 1.01 Articolo in rivista | s40169-017-0181-2.pdf |
| Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform | Carolina B. Moraes, Gesa Witt, Maria Kuzikov, Bernhard Ellinger, Theodora Calogeropoulou, Kyriakos C. Prousis, Stefano Mangani, Flavio Di Pisa, Giacomo Landi, Lucia Dello Iacono, Cecilia Pozzi, Lucio H. Freitas-Junior, Bruno dos Santos Pascoalino, Claudia P. Bertolacini, Birte Behrens, Oliver Keminer, Jennifer Leu, Markus Wolf, Jeanette Reinshagen, Anabela Cordeiro-da-Silva, Nuno Santarem, Alberto Venturelli, Stephen Wrigley, Deepa Karunakaran, Bethlehem Kebede, Ina Pöhner, Wolfgang Müller, Joanna Panecka-Hofman, Rebecca C. Wade, Martina Fenske, Joachim Clos, José María Alunda, María Jesús Corral, Elisa Uliassi, Maria Laura Bolognesi, Pasquale Linciano, Antonio Quotadamo, Stefania Ferrari, Matteo Santucci, Chiara Borsari, Maria Paola Costi, Sheraz Gul | 2019-01-01 | SLAS DISCOVERY | - | 1.01 Articolo in rivista | - |
| Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease | Chalupova K.; Korabecny J.; Bartolini M.; Monti B.; Lamba D.; Caliandro R.; Pesaresi A.; Brazzolotto X.; Gastellier A.-J.; Nachon F.; Pejchal J.; Jarosova M.; Hepnarova V.; Jun D.; Hrabinova M.; Dolezal R.; Zdarova Karasova J.; Mzik M.; Kristofikova Z.; Misik J.; Muckova L.; Jost P.; Soukup O.; Benkova M.; Setnicka V.; Habartova L.; Chvojkova M.; Kleteckova L.; Vales K.; Mezeiova E.; Uliassi E.; Valis M.; Nepovimova E.; Bolognesi M.L.; Kuca K. | 2019-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
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