Sfoglia per Autore
Affinity and selectivity at M2 and M3 muscarinic receptor subtypes of cyclic and open oxygenated analogues of 4-DAMP
1992 Tumiatti V.; Recanatini M.; Minarini A.; Melchiorre C.; Chiarini A.; Budriesi R.; Bolognesi M.L.
Synthesis and Biological Activity of Some Methoctramine-Related Tetraamines Bearing a 11-Acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one Moiety as Antimuscarinics: A Second Generation of Highly Selective M2 Muscarinic Receptor Antagonists
1993 Melchiorre C.; Bolognesi M.L.; Chiarini A.; Minarini A.; Spampinato S.
Binding profile of the selective muscarinic receptor antagonist tripitramine
1994 Maggio R.; Barbier P.; Bolognesi M.L.; Minarini A.; Tedeschi D.; Melchiorre C.
Design, Synthesis, and Biological Activity of Methoctramine-Related Tetraamines Bearing an 11-Acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one Moiety: Structural Requirements for Optimum Occupancy of Muscarinic Receptor Subtypes As Revealed by Symmetrical and Unsymmetrical Polyamines
1994 Minarini A.; Bolognesi M.L.; Budriesi R.; Canossa M.; Chiarini A.; Spampinato S.; Melchiorre C.
In vitro characterization of tripitramine, a polymethylene tetraamine displaying high selectivity and affinity for muscarinic M2 receptors
1995 Chiarini A.; Budriesi R.; Bolognesi M.L.; Minarini A.; Melchiorre C.
Synthesis, muscarinic blocking activity and molecular modeling studies of 4-DAMP-related compounds
1995 Recanatini M.; Tumiatti V.; Budriesi R.; Chiarini A.; Sabatino P.; Bolognesi M.L.; Melchiorre C.
Opioid antagonist activity of naltrexone-derived bivalent ligands: Importance of a properly oriented molecular scaffold to guide "address" recognition at κ opioid receptors
1996 Bolognesi M.; Ojala W.H.; Gleason W.B.; Griffin J.F.; Farouz-Grant F.; Larson D.L.; Takemori A.E.; Portoghese P.S.
Tetraamines as lead compounds for the design of neurotransmitter receptor ligands:Focus on α-adrenergic and muscarinic receptors recognition
1996 Melchiorre C.; Angeli P.; Bolognesi M.L.; Budriesi R.; Cacciaguerra S.; Chiarini A.; Crucianelli M.; Giardina D.; Gulini U.; Marucci G.; Minarini A.; Spampinato S.; Tumiatti V.
Universal template approach to drug design: Polyamines as selective muscarinic receptor antagonists
1998 Bolognesi M.L.; Minarini A.; Budriesi R.; Cacciaguerra S.; Chiarini A.; Spampinato S.; Tumiatti V.; Melchiorre C.
Antagonist binding profile of the split chimeric muscarinic m2-trunc/m3-tail receptor
1998 Barbier P.; Colelli A.; Bolognesi M.L.; Minarini A.; Tumiatti V.; Corsini G.U.; Melchiorre C.; Maggio R.
Search for selective antagonists at α1-adrenoreceptors: Neutral or negative antagonism?
1998 Melchiorre C.; Bolognesi M.L.; Budriesi R.; Chiarini A.; Giardina D.; Minarini A.; Quaglia W.; Leonardi A.
Design, synthesis, and biological activity of prazosin-related antagonists. Role of the piperazine and furan units of prazosin on the selectivity for α1-adrenoreceptor subtypes
1998 Bolognesi M.L.; Budriesi R.; Chiarini A.; Poggesi E.; Leonardi A.; Melchiorre C.
Design, synthesis, and biological evaluation of symmetrically and unsymmetrically substituted methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists
1999 Rosini M.; Budriesi R.; Bixel M.G.; Bolognesi M.L.; Chiarini A.; Hucho F.; Krogsgaard-Larsen P.; Mellor I.R.; Minarini A.; Tumiatti V.; Usherwood P.N.R.; Melchiorre C.
WB 4101-related compounds. 2. Role of the ethylene chain separating amine and phenoxy units on the affinity for α1-adrenoreceptor subtypes and 5-HT(1A) receptors
1999 Bolognesi M.L.; Budriesi R.; Cavalli A.; Chiarini A.; Gotti R.; Leonardi A.; Minarini A.; Poggesi E.; Recanatini M.; Rosini M.; Tumiatti V.; Melchiorre C.
Structure-activity relationship and site of binding of polyamine derivatives at the nicotinic acetylcholine receptor
2000 Bixel M.G.; Krauss M.; Liu Y.; Bolognesi M.L.; Rosini M.; Mellor I.S.; Usherwood P.N.R.; Melchiorre C.; Koji N.; Hucho F.
α1-Adrenoreceptor antagonists bearing a quinazoline or a benzodioxane moiety
2000 Melchiorre C.; Angeli P.; Bolognesi M.L.; Chiarini A.; Giardina D.; Gulini U.; Leonardi A.; Marucci G.; Minarini A.; Pigini M.; Quaglia W.; Rosini M.; Tumiatti V.
Prejunctional muscarinic inhibitory control of acetylcholine release in the human isolated detrusor: Involvement of the M4 receptor subtype
2000 D'Agostino G.; Bolognesi M.L.; Lucchelli A.; Vicini D.; Balestra B.; Spelta V.; Melchiorre C.; Tonini M.
Analysis of the muscarinic receptor subtype mediating inhibition of the neurogenic contractions in rabbit isolated vas deferens by a series of polymethylene tetra-amines
2001 Budriesi R.; Cacciaguerra S.; Di Toro R.; Bolognesi M.L.; Chiarini A.; Minarini A.; Rosini M.; Spampinato S.; Tumiatti V.; Melchiorre C.
Binding of polyamine-containing toxins in the vestibule of the nicotinic acetylcholine receptor ion channel
2001 Bixel M.Gabriele; Krauss M.; Weise C.; Bolognesi M.L.; Rosini M.; Usherwood P.N.R.; Melchiorre C.; Hucho F.
Design, synthesis, and biological activity of methoctramine-related polyamines as putative Gi protein activators
2001 Melchiorre C.; Bolognesi M.L.; Budriesi R.; Ghelardini C.; Chiarini A.; Minarini A.; Rosini M.; Tumiatti V.; Wade E.J.
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