It is time for agent-based modelling (ABM) to trespass the "me too" stage, so as to deliver up to its promises. To this end, agent-based techniques should be tested against scenarios that have proven to be too complex for traditional approaches. In this paper, we take a complex problem in the biological domain — lineage commitment of Hematopoietic Stem Cells (HSC) —, and introduce an articulated agent-based model accounting for both intra- and inter-cellular aspects. An implementation of the model in MASON is presented, and the first simulation results are discussed.
Lineage commitment of hematopoietic stem cells: An agent-based model / Sara Montagna; Andrea Omicini; Marco Alberti. - STAMPA. - (2008), pp. 201-214. (Intervento presentato al convegno 10º Convegno Associazione Italiana per l’Intelligenza Artificiale (AI*IA 2008), Workshop ”Multi-agent Systems & Bioinformatics” (MAS&BIO 2008) tenutosi a Cagliari, Italy nel 11 September 2008).
Lineage commitment of hematopoietic stem cells: An agent-based model
MONTAGNA, SARA;OMICINI, ANDREA;
2008
Abstract
It is time for agent-based modelling (ABM) to trespass the "me too" stage, so as to deliver up to its promises. To this end, agent-based techniques should be tested against scenarios that have proven to be too complex for traditional approaches. In this paper, we take a complex problem in the biological domain — lineage commitment of Hematopoietic Stem Cells (HSC) —, and introduce an articulated agent-based model accounting for both intra- and inter-cellular aspects. An implementation of the model in MASON is presented, and the first simulation results are discussed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
